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Online Library: Immune System

The following pages provide an overview of the most recent research and clinical studies about the health benefits of micronutrients in supporting the immune system. This collection of scientific facts proves that anyone who privately or publicly questions the health value of micronutrients does not serve YOUR health, or the health of the people, but rather the multi-billion dollar investment 'business with disease' based on patented pharmaceutical drugs.

We encourage you to forward the link to this important online library on natural health – one of the largest ones in the world – to your friends. You may also print out the articles you find most important for your own health condition and share them with your doctor. Any responsibly acting health professional will be grateful to receive such science-based health education.

Vitamin E Supplementation and in Vivo Immune Response in Healthy Elderly Subjects

Source: JAMA 1997 May 7;277(17):1380-6

Author: Meydani SN; Meydani M; Blumberg JB; Leka LS; Siber G; Loszewski R; Thompson C; Pedrosa MC; Diamond RD; Stollar BD

Affiliation: Nutritional Immunology Laboratory, Jean Mayer

Abstract: The study of a total of 88 free-living, healthy subjects at least 65 years of age determine whether long-term supplementation with vitamin E enhances in vivo, clinically relevant measures of cell-mediated immunity in healthy elderly subjects. Supplementation with vitamin E for 4 months improved certain clinically relevant indexes of cell-mediated immunity in healthy elderly. The results indicate that a level of vitamin E greater than currently recommended enhances certain clinically relevant in vivo indexes of T-cell-mediated function in healthy elderly persons. No adverse effects were observed with vitamin E supplementation.

Protective Effects of the Glutathione Redox Cycle and Vitamin E on Cultured Fibroblasts Infected by Mycoplasma Pneumoniae.

Source: Infect Immun 1986 Apr;52(1):240-4

Author: Almagor M; 1,2 Kahane I2 Gilon C3 Yatziv S1

Affiliation: Department of Pediatrics, Hadassah University Hospital,1 Department of Membrane and Ultrastructure Research, The Hebrew University-Hadassah Medical School,2 and Department of Organic Chemistry, The Hebrew University,3 Jerusalem 91010, Israel

Abstract: The study examined the role of the glutathione (GSH) redox cycle and vitamin E as antioxidant defense systems in normal human cultured skin fibroblasts infected by virulent Mycoplasma pneumoniae. In cells infected for 20 h, catalase activity was inhibited by 75% and the intracellular GSH decreased to 32% of its normal values. GSH peroxidase and oxidized glutathione (reductase activities in the infected cells were unaffected.) The data indicate that the oxidative damage induced in M. pneumoniae-infected cells due to the increase in intracellular levels of H2O2 and O2- is limited by the host cell GSH redox cycle and by supplementation with vitamin E.

Immune-enhancing role of vitamin C and zinc and effect on clinical conditions

Source: Annals of Nutrition & Metabolism 2006; 50(2): 85-94

Author: Wintergerst ES, Maggini S, Hornig DH

Affiliation: Bayer Consumer Care Ltd., Basel, Switzerland

Abstract: Vitamin C concentrations in the plasma and leukocytes rapidly decline during infections and stress. Supplementation of vitamin C was found to improve components of the human immune system such as antimicrobial and natural killer cell activities, lymphocyte proliferation, chemotaxis, and delayed-type hypersensitivity. Vitamin C contributes to maintaining the redox integrity of cells and thereby protects them against reactive oxygen species generated during the respiratory burst and in the inflammatory response. Likewise, zinc undernutrition or deficiency was shown to impair cellular mediators of innate immunity such as phagocytosis, natural killer cell activity, and the generation of oxidative burst. Therefore, both nutrients play important roles in immune function and the modulation of host resistance to infectious agents, reducing the risk, severity, and duration of infectious diseases. This is of special importance in populations in which insufficient intake of these nutrients is prevalent. In the developing world, this is the case in low- and middle-income countries, but also in subpopulations in industrialized countries, e.g. in the elderly. A large number of randomized controlled intervention trials with intakes of up to 1 g of vitamin C and up to 30 mg of zinc are available. These trials document that adequate intakes of vitamin C and zinc ameliorate symptoms and shorten the duration of respiratory tract infections including the common cold. Furthermore, vitamin C and zinc reduce the incidence and improve the outcome of pneumonia, malaria, and diarrhea infections, especially in children in developing countries.

The impact of vitamin A supplementation on the immune system of vitamin A-deficient children.

Source: Int J Vitam Nutr Res. 2010;80(3):188-96.

Author: de Azevedo Paiva A, Rondó PH, Rehder Vaz-de-Lima L, de Freitas Oliveira C, Ueda M, Gonçalves-Carvalho C, Reinaldo LG.

Affiliation: Department of Nutrition, Federal University of Teresina, Piaui, Brazil.

Abstract: The study was carried out in 631 children from 36 to 83 months of age. The authors state, "Vitamin A had an effect on the recruitment of T and B lymphocytes to the circulation of children with hypovitaminosis A and anemia."