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Online Library: Elderliness

The following pages provide an overview of the most recent research and clinical studies about the health benefits of micronutrients in fighting Elderliness . This collection of scientific facts proves that anyone who privately or publicly questions the health value of micronutrients does not serve YOUR health, or the health of the people, but rather the multi-billion dollar investment 'business with disease' based on patented pharmaceutical drugs.

We encourage you to forward the link to this important online library on natural health – one of the largest ones in the world – to your friends. You may also print out the articles you find most important for your own health condition and share them with your doctor. Any responsibly acting health professional will be grateful to receive such science-based health education.

Creatine Supplementation during Resistance Training in Older Adults-a Meta-analysis.


Author: Devries MC, Phillips SM.

Affiliation: Exercise Metabolism Research Group (EMRG), Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada

Abstract: Age-related sarcopenia and dynapenia have negative effects on strength and the ability to perform activities of daily living. Resistance training (RT) increases muscle mass and strength in older adults and is an established countermeasure for sarcopenia and dynapenia and creatine may enhance this effect. The researchers aimed to determine whether the addition of Cr to RT increased gains in muscle mass, strength and function in older adults over RT alone by conducting a systematic review and meta-analysis. Pubmed and Healthstar databases were searched. Randomized, placebo (PL) controlled trials that involved older adults supplemented with Cr and including RT regimes (>6wk) were included. Data were analyzed using fixed or random (if data were heterogeneous) effects meta-analysis using RevMan 5. The meta-analysis comprised 357 older adults with 12.6 of RT. Cr+RT increased total body mass and fat free mass with no effect on fat mass as compared with RT alone. Cr+RT increased chest press and leg press 1RM to a greater extent than RT alone, with no difference in effect on knee extension or biceps curl 1RM, isokinetic or isometric knee extension peak torque. Cr+RT had a greater effect than RT alone on the 30s chair stand test. Retention of muscle mass and strength is integral to healthy aging. The results from this meta-analysis are encouraging in supporting a role for Cr supplementation during RT in healthful aging by enhancing muscle mass gain, strength and functional performance; however, the limited number of studies indicates further work is needed.

Vitamin D deficiency in a cohort over 65 years: Prevalence and association with sociodemographic and health factors


Author: Mateo-Pascual C, et al.

Affiliation: Centro de Salud Fuencarral, Atención Primaria de Madrid, Madrid, España; Miembro de IdiPAZ; Servicio de Geriatría, Hospital Universitario La Paz (HULP), Madrid, España.

Abstract: Vitamin D deficiency is common in the elderly, especially among institutionalized and/or hip fracture patients. However, there are few population studies on the prevalence of this deficiency in the general population over 64 years in our environment. The aim of this study was to determine the prevalence of vitamin D deficiency in an urban population cohort of over 64 years, and analyze its relationship with sociodemographic, climatic, and health factors. This was a cross-sectional study from Peñagrande cohort a population-based cohort consisting of people over 64 years. We determined 25-hydroxyvitamin D levels, and recorded sociodemographic data (age, sex, marital status, education, socioeconomic status), season of measurement and health variables (comorbidity, obesity, malnutrition, renal failure, cognitive impairment, vitamin D supplements, and disability). A total of 468 individuals with a mean age of 76.0 years were included, of which 53.4% were women. The mean value of vitamin D was 20.3±11.7ng/mL. The large majority had a vitamin insufficiency (≤30ng/ml), and 35.2% showed severe vitamin deficiency (≤15ng/ml). Vitamin insufficiency increases linearly with age and was associated with low socioeconomic status. Severe vitamin D deficiency increases with age, female gender and with cognitive impairment. The prevalence of vitamin D deficiency in people over 65 years of age is high. It would be advisable to determine the vitamin D values in the high risk elderly in order to introduce measures of supplementation in those with inadequate levels.

Vitamin A status regulates glucocorticoid availability in Wistar rats: consequences on cognitive functions and hippocampal neurogenesis?


Author: Bonhomme D, et al.

Affiliation: INRA, Nutrition et Neurobiologie Intégrée (NutriNeuro), Bordeaux, France; University of Bordeaux, Nutrition et Neurobiologie Intégrée (NutriNeuro), Bordeaux, France.

Abstract: A disruption of the vitamin A signaling pathway has been involved in age-related memory decline and hippocampal plasticity alterations. Using vitamin A deficiency (VAD), a nutritional model leading to a hyposignaling of the retinoid pathway, the researchers have recently demonstrated that retinoic acid (RA), the active metabolite of vitamin A, is efficient to reverse VAD-induced spatial memory deficits and adult hippocampal neurogenesis alterations. Besides, excess of glucocorticoids (GCs) occurring with aging is known to strongly inhibit hippocampal plasticity and functions and few studies report on the counteracting effects of RA signaling pathway on GCs action. Here, the researchers have addressed whether the modulation of brain GCs availability could be one of the biological mechanisms involved in the effects of vitamin A status on hippocampal plasticity and functions. Thus, the researchers have studied the effects of a vitamin A-free diet for 14 weeks and a 4-week vitamin A supplementation on plasma and hippocampal corticosterone (CORT) levels in Wistar rats. They have also investigated corticosteroid binding globulin (CBG) binding capacity and 11beta-Hydrosteroid Dehydrogenase type 1 (11â-HSD1) activity, both important modulators of CORT availability at the peripheral and hippocampal levels respectively. Interestingly, the study shows that the vitamin A status regulates levels of free plasma CORT and hippocampal CORT levels, by acting through a regulation of CBG binding capacity and 11â-HSD1 activity. Moreover, the results suggest that increased CORT levels in VAD rats could have some deleterious consequences on spatial memory, anxiety-like behavior and adult hippocampal neurogenesis whereas these effects could be corrected by a vitamin A supplementation. Thus, the modulation of GCs availability by vitamin A status is an important biological mechanism that should be taken into account in order to prevent age-related cognitive decline and hippocampal plasticity alterations.