Get Educated!

Welcome to our online library!

Online Library: Osteoarthritis

The following pages provide an overview of the most recent research and clinical studies about the health benefits of micronutrients in fighting osteoarthritis. This collection of scientific facts proves that anyone who privately or publicly questions the health value of micronutrients does not serve YOUR health, or the health of the people, but rather the multi-billion dollar investment 'business with disease' based on patented pharmaceutical drugs.

We encourage you to forward the link to this important online library on natural health ? one of the largest ones in the world ? to your friends. You may also print out the articles you find most important for your own health condition and share them with your doctor. Any responsibly acting health professional will be grateful to receive such science-based health education.

Symptomatic effect of chondroitin sulfate 4&6 in hand osteoarthritis the finger osteoarthritis chondroitin treatment study (FACTS)

Source: Arthritis and rheumatism, 2011 Sep 6. doi: 10.1002/art.30574. [Epub ahead of print]

Author: Gabay C, Medinger-Sadowski, et al

Affiliation: Hopitaux Universitaires de Geneve, Geneva, Switzerland

Abstract: Chondroitin sulfate (CS) significantly decreased pain and improved hand function in patients with osteoarthritis (OA) of the hand. The single-center, placebo-controlled FACTS trial included 162 patients with OA of the hand who met inclusion criteria-spontaneous hand pain on the visual analogue scale (VAS) of 40 mm (scale 0-100) or more and Functional Index for Hand OA (FIHOA) level of 6 (scale 0-30). Subjects were randomly assigned to receive either 800 mg per day of chrondroitin sulfate or placebo, once daily, for 6 months. Researchers reported a decrease in global hand pain, as well as significantly improved hand function and reduction in morning stiffness for participants taking chondroitin sulfate versus placebo. This study indicates that chrondroitin sulfate may have a positive clinical effect on patients with osteoarthritis of the hand.

Regulation of osteoarthritis by omega-3 (n-3) polyunsaturated fatty acids in a naturally occurring model of disease

Source: Osteoarthritis Cartilage 2011; 19(9): 11501157

Author: Knott L, Avery NC, Hollander AP and Tarlton JF

Affiliation: Matrix Biology, Div. VPII, University of Bristol, Veterinary School, Langford, UK; Stem Cell Biology, Cellular and Molecular Medicine, University of Bristol, UK

Abstract: To examine effects of high omega-3 (n-3) polyunsaturated fatty acid (PUFA) diets on development of osteoarthritis (OA) in a spontaneous guinea pig model, and to further characterize pathogenesis in this model. Modern diets low in n-3 PUFAs have been linked with increases in inflammatory disorders, possibly including OA. However, n-3 is also thought to increases bone density, which is a possible contributing factor in OA. Therefore in this study the authors aim to determine the net influence of n-3 in disease development. OA-prone Dunkin-Hartley (DH) Guinea pigs were compared with OA-resistant Bristol Strain-2s (BS2) each fed a standard or an n-3 diet from 10 to 30 weeks (10/group). Scientists examined cartilage and subchondral bone pathology by histology, and biochemistry, including collagen cross-links, matrix metalloproteinases (MMPs), alkaline phosphatase, glycosaminoglycan (GAG), and denatured type II collagen. Dietary n-3 reduced disease in OA-prone animals. Most cartilage parameters were modified by n-3 diet towards those seen in the non-pathological BS2 strain significantly active MMP-2, lysyl-pyridinoline and total collagen cross-links the only exception being pro MMP-9 which was lower in the BS2, yet increased with n-3. GAG content was higher and denatured type II lower in the n-3 group. Subchondral bone parameters in the DH n-3 group also changed towards those seen in the non-pathological strain, significantly calcium:phosphate ratios and epiphyseal bone density. Conclusion: Dietary n-3 PUFA reduced OA in the prone strain, and most disease markers were modified towards those of the non-OA strain, though not all significantly so. Omega-3 did not increase markers of pathology in either strain.