Online Library: Fibromyalgia
The following pages provide an overview of the most recent research and clinical studies about the health benefits of micronutrients in fighting fibromyalgia. This collection of scientific facts proves that anyone who privately or publicly questions the health value of micronutrients does not serve YOUR health, or the health of the people, but rather the multi-billion dollar investment 'business with disease' based on patented pharmaceutical drugs.
We encourage you to forward the link to this important online library on natural health – one of the largest ones in the world – to your friends. You may also print out the articles you find most important for your own health condition and share them with your doctor. Any responsibly acting health professional will be grateful to receive such science-based health education.
Can coenzyme q10 improve clinical and molecular parameters in fibromyalgia?
Affiliation: 1 Departamento de Citología e Histología Normal y Patológica, Facultad de Medicina, Universidad de Sevilla , Sevilla, Spain .
Abstract: Fibromyalgia (FM) is a complex disorder that affects up to 5% of the general population worldwide. Its pathophysiological mechanisms are difficult to identify and current drug therapies demonstrate limited effectiveness. Both mitochondrial dysfunction and coenzyme Q10 (CoQ10) deficiency have been implicated in FM pathophysiology. The authors have investigated the effect of CoQ10 supplementation. They carried out a randomized, double-blind, placebo-controlled trial to evaluate clinical and gene expression effects of forty days of CoQ10 supplementation (300 mg/day) on 20 FM patients. An important clinical improvement was evident after CoQ10 versus placebo treatment showing a reduction of FIQ, and a most prominent reduction in pain, fatigue, and morning tiredness subscales from FIQ. Furthermore, the authors observed an important reduction in the pain visual scale and a reduction in tender points, including recovery of inflammation, antioxidant enzymes, mitochondrial biogenesis, and AMPK gene expression levels, associated with phosphorylation of the AMPK activity. Conclusion: These results lead to the hypothesis that CoQ10 have a potential therapeutic effect in FM, and indicate new potential molecular targets for the therapy of this disease. AMPK could be implicated in the pathophysiology of FM.