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Online Library: Allergies

The following pages provide an overview of the most recent research and clinical studies about the health benefits of micronutrients in fighting allergies. This collection of scientific facts proves that anyone who privately or publicly questions the health value of micronutrients does not serve YOUR health, or the health of the people, but rather the multi-billion dollar investment 'business with disease' based on patented pharmaceutical drugs.

We encourage you to forward the link to this important online library on natural health – one of the largest ones in the world – to your friends. You may also print out the articles you find most important for your own health condition and share them with your doctor. Any responsibly acting health professional will be grateful to receive such science-based health education.

Higher serum folate levels are associated with a lower risk of atopy and wheeze.

Source: The journal of allergy and clinical immunology 2009;123(6):1253-9.e2.

Author: Matsui EC, Matsui W.

Affiliation: Division of Pediatric Allergy and Immunology, Johns Hopkins School of Medicine, Baltimore, USA.

Abstract: Folic acid is known to be associated with inflammatory diseases, but the relationship between folic acid and allergic diseases is unclear. The purpose of this study was to examine the relationship between serum folate levels and markers of atopy, wheeze, and asthma. Data were obtained from the 2005-2006 National Health and Nutrition Examination Survey in which serum folate and total IgE levels* were measured in 8083 subjects 2 years of age and older. A high total IgE level was defined as greater than 100 kU/L. Allergen-specific IgE levels were measured for a panel of 5 common aeroallergens. Atopy was defined as at least 1 positive allergen-specific IgE level. Doctor-diagnosed asthma and wheeze in the previous 12 months were assessed by means of questionnaire. Conclusion: Serum folate levels were inversely associated with total IgE levels. The odds of a high total IgE level, atopy, and wheeze decreased across quintiles of serum folate levels, indicating a dose-response relationship between serum folate levels and these outcomes. Each of these associations remained statistically significant after adjusting for age, sex, race/ethnicity, and poverty index ratio. Higher folate levels were also associated with a lower risk of doctor-diagnosed asthma.

* Specific Allergy related Immunoglobulin E (IgE) is the antibody found in our blood and tissues which mediates allergy. Allergy sufferers have raised levels of IgE and it can be measured on allergy testing the blood by RAST tests and also with Skin Prick Tests.

Vitamin D and K status influences bone mineral density and bone accrual in children and adolescents with celiac disease*.

Source: European journal of clinical nutrition 2011 Oct. doi: 10.1038/ejcn.2011.176. [Epub ahead of print]

Author: Mager DR, Qiao J, Turner J.

Affiliation: Department of Agriculture, Food and Nutritional Science, University of Alberta, Canada, Department of Pediatric Gastroenterology and Nutrition, University of Alberta, Canada.

Abstract: Background/Objectives:Children with celiac disease (CD) are at risk for decreased bone mineral density (BMD) because of fat-soluble vitamin malabsorption, inflammation and/or under-nutrition. The study objective was to determine the interrelationships between vitamin K/D status and lifestyle variables on BMD in children and adolescents with CD at diagnosis and after 1 year on the gluten-free diet (GFD).Therefore children and adolescents aged 3-17 years with biopsy proven CD at diagnosis and after 1 year on the GFD were studied. BMD was measured using dual-energy X-ray absorptiometry. Relevant variables included: anthropometrics, vitamin D/K status, diet, physical activity and sunlight exposure. Whole-body and lumbar-spine BMD-z scores were low at diagnosis (10-20%) and after 1 year (30-32%) in the children, independent of symptoms. Whole-body BMD-z scores and serum levels of 25(OH) vitamin D were significantly lower in older children (>10 years) when compared with younger children. Forty-three percent had suboptimal vitamin D status (25(OH)-vitamin D <75 nmol/l) at diagnosis; resolving in nearly half after 1 year on the GFD. Twenty-five percent had suboptimal vitamin K status at diagnosis; all resolved after 1 year. Conclusions: Children and adolescents with CD are at risk for suboptimal bone health at time of diagnosis and after 1 year on GFD; likely due in part to suboptimal vitamin D/K status. Therapeutic strategies aimed at optimizing vitamin K/D intake may contribute to improve BMD in children with CD.

*Celiac disease is intolerance to gluten, a protein in wheat, rye and barley

Allergies and micronutrients

Steroid Response After Long–Term Treatment with Oral N–Acetylcysteine in Patients with Chronic Obstructive Bronchitis

Source: Ugeskr Laeger. 1989 Nov 13;151(46):2076-8

Author: Evald T, Hansen M, Balsløv S, Brorson-Riis L, Hansen NC, Maltbaek N, Thorshauge H.

Affiliation:

Abstract: The significance of long-term treatment with N-acetylcystein (NAC) for the steroid response on pulmonary function and general symptoms was investigated in patients with chronic bronchitis and moderate respiratory obstruction. All of the patients had received preliminary treatment with oral NAC in a dosage of 1,200 mg daily (Mucomyst Retard) or a placebo for 22 weeks in a double-blind design. It is concluded that, in this investigation, no clinically relevant effect of long-term preliminary treatment with NAC on the results of a steroid test was observed in patients with chronic bronchitis and moderate respiratory obstruction.

Effectiveness of Oral N -Acetylcysteine in a Rat Experimental Model of Asthma

Source: Pharmacological Research, Volume 45, Issue 2, February 2002, Pages 135-140

Author: S. Blesa,¹ J. Cortijo,¹ M. Martinez-losa,¹ M. Mata,¹ E. Seda,¹ F. Santangelo² and E. J. Morcillo¹

Affiliation: Department of Pharmacology, Faculty of Medicine, University of Valencia, Av. Blasco Ibanez 15, E-46010 Valencia, Spain,¹ Zambon Group Spa, Via Lillo del Duca 10, 20091 Bresso (Milan), Italy ²

Abstract: Allergies are often associated with asthma. Oxidative stress appears to be relevant to asthma pathogenesis. Therefore, the effectivenss of the antioxidant N -acetylcysteine was examined on antigen-induced pulmonary responses in sensitized Brown–Norway rats. The study indicates that oral N -acetylcysteine shows beneficial effects in an in vivo model of experimental asthma, which confirm and extend the previous positive findings obtained in other models of lung injury.

N-Acetylcysteine Attenuates TNF-[alpha]-Dependent Reduction of IL-4-Induced Fc[epsilon]RII Expression in Human Monocytes.

Source: European Journal of Allergy & Clinical Immunology

Author: Hashimoto, S.Gon, Y.Nakayama, T. Yoshida, S. Hayashi, S. Maruoka, S.Yodoi, J. Horie, T.

Affiliation: First Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan

Abstract: The study we hypothesizes that TNF-α-dependent reduction of IL-4-induced FcεRII expression in monocytes might be mediated through the ROIs-activated mechanism. The study examined the effect of NAC on TNF-α-dependent reduction of IL-4-induced FcεRII expression in human monocytes. NAC attenuated TNF-α-dependent reduction of IL-4-induced FcεRII mRNA expression. by attenuating TNF-α-dependent reduction of FcεRII mRNA expression. Similarly, the structurally unrelated antioxidant, pyrrolidine dithiocarbamate (PDTC), also effectively attenuated this reduction. These results indicate that an ROIs-activated and antioxidant-sensitive mechanism might be involved in TNF-α-dependent reduction of IL-4-induced FcεRII expression in monocytes.

N-Acetylcysteine and Disease Progression in COPD (Chronic Obstructive Pulmonary Disease)

Source: Thorax 2005;60:622

Author: K. Satkunam

Affiliation: Newham University Hospital, London, UK;

Abstract: It is known that oxidative stress plays an important role in the pathogenesis of chronic obstructive pulmonary disease (COPD). In this study the anti-oxidant N-acetylcysteine (NAC) was used to assess whether this drug could reduce the rate of lung function decline, reduce the yearly exacerbation rate, or improve clinical outcomes. 523 patients were randomised to receive either 600 mg NAC daily or placebo over a 3 year period. No significant differences were found in the rate of FEV1 decline (54 ml/year NAC v 47 ml/year placebo) or number of exacerbations per year (1.25 NAC v 1.29 placebo)

N-3 Polyunsaturated Fatty Acids and Allergic Disease.

Source: Current Opinion in Clinical Nutrition and Metabolic Care 2004, Volume 7(2), pp 123-129

Author: Prescott, Susan L., Calder, Philip C

Affiliation: School of Paediatrics and Child Health, University of Western Australia, PO Box D184, Princess Margaret Hospital, Perth, WA 6001, Australia. susanp@ichr.uwa.edu.au

Abstract: The study examines the evidence for a potential role of changing dietary intake of omega-3 polyunsaturated fatty acids in the development, treatment and prevention of allergic diseases. Two recent preliminary reports in infants suggest that dietary omega-3 polyunsaturated fatty acid supplements in pregnancy or in the early postnatal period could have immunomodulatory properties and associated clinical effects, although more studies are now needed. Novel synthetic polyunsaturated fatty acids with more potent and selective antiinflammatory effects may also provide safe therapeutic and preventive strategies in the future.

Autoimmune Disease and Allergy are Controlled by Vitamin C Treatment

Source: In-Vivo. 1994 Mar-Apr; 8(2): 251-7

Author: Kodama, M : Kodama, T : Murakami, M : Kodama, M

Affiliation: Kodama Research Institute of Preventive Medicine, Nagoya, Japan.

Abstract: The study investigates the problem of whether or not vitamin C administration may help control autoimmune disease and allergy by stimulating the glucocorticoid mechanism of a patient with an immune disorder. The study shows that vitamin C injection or infusion treatments induced an increase of plasma glucocorticoid activity with a delay of about 2 hours, as assessed in terms of the eosinophil count and plasma cortisol concentration. Within 2 hours there was a remarkable decline of plasma cortisol that suggests the presence of some cortisol absorber, of which the function was triggered by vitamin C. The same vitamin C treatments also accelerated diuresis and 17-OHCS excretion